[en] The eyes from six rats were fixed at the recovery site in Russia after they had circled the earth for 19.5 d in a 62.8 degree orbit. The eyes of six more flight rats were fixed 25 d later. These two preparations and eyes exposed to 1000 rad of neon and argon were compared to obtain data on possible radiation effects on the retina. Most of the flight eye tissue was normal; however, necrotic nuclei were found in the outer nuclear layer and channels were located in the outer segment area. Macrophages were seen between the pigment layer and outer segments. Comparison of the Day zero and 25-d postflight eyes suggested some possible recovery. Light flashes seen by space travelers and damage from cosmic rays appear to arise from two different sites of interaction. The flashes are created by cosmic ray transversal of the outer segments while pathologic change, when it occurs, is quite possibly from interaction with some part of the nucleus. Nevertheless, direct interaction with other cellular components could also occur. Other factors, such as secondaries from spaceraft shielding, may play an important role