[en] This annual report of the Physics, Computer Science and Mathematics Division describes the scientific research and other work carried out within the Division during 1977. The Division is concerned with work in experimental and theoretical physics, with computer science and applied mathematics, and with the operation of a computer center. The major physics research activity is in high-energy physics, although there is a relatively small program of medium-energy research. The High Energy Physics research program in the Physics Division is concerned with fundamental research which will enable man to comprehend the nature of the physical world. The major effort is now directed toward experiments with positron-electron colliding beam at PEP. The Medium Energy Physics program is concerned with research using mesons and nucleons to probe the properties of matter. This research is concerned with the study of nuclear structure, nuclear reactions, and the interactions between nuclei and electromagnetic radiation and mesons. The Computer Science and Applied Mathematics Department engages in research in a variety of computer science and mathematics disciplines. Work in computer science and applied mathematics includes construction of data bases, computer graphics, computational physics and data analysis, mathematical modeling, and mathematical analysis of differential and integral equations resulting from physical problems. The Computer Center provides large-scale computational support to LBL's scientific programs. Descriptions of the various activities are quite short; references to published results are given. 24 figures