[en] CIRENE is a heavy-water moderated, boiling water cooled pressure tube reactor. Fuel is natural uranium. A variety of breaks in the primary coolant system have been postulated for the analysis of the CIRENE Latina Plant (now under construction) such as double-end break of inlet header, downcomer, steam line and inlet feeders. The basic tool for analysis is the TILT-N Code which has been purposely developed for simulating the nuclear, thermal and hydrodynamic behaviour of the CIRENE core and associated heat transport system. An extensive full-scale test programme has been carried out by CNEN and CISE which fully confirms the adequacy of the model. The main results of the analysis show that maximum temperatures are far from those leading to significant fuel damage and that adequate core cooling is provided over the whole transient. (author)