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Shiue, C.Y.; Fowler, J.S.; MacGregor, R.R.; Wolf, A.P.
Brookhaven National Lab., Upton, NY (USA)1979
Brookhaven National Lab., Upton, NY (USA)1979
AbstractAbstract
[en] A method for the rapid synthesis of high specific activity of [18F]-5-fluorouridine is described. The 20Ne(d,α)18F nuclear reaction is used to produce high specific activity, anhydrous [18F]-F2 at the Brookhaven National Laboratory 60'' cyclotron. Fluorination of 2',3',5'-tri-0-acetyluridine with [18F]-F2 in glacial acetic acid at room temperature followed by hydrolysis with sodium methoxide in methanol gives [18F]-5-fluorouridine with a radiochemical yield of 5 to 7% in a synthesis time of 90 minutes from EOB. The compound is required for the study of RNA synthesis and tumor growth rates in vivo
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1979; 8 p; 2. international symposium on radiopharmaceuticals; Seattle, WA, USA; 18 - 23 Mar 1979; CONF-790321--7; Available from NTIS., PC A02/MF A01
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Report
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Conference
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ACCELERATORS, ANTIMETABOLITES, ANTIMITOTIC DRUGS, AZINES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, CYCLIC ACCELERATORS, CYCLOTRONS, DISEASES, DRUGS, FLUORINE ISOTOPES, HETEROCYCLIC COMPOUNDS, HOURS LIVING RADIOISOTOPES, HYDROXY COMPOUNDS, ISOCHRONOUS CYCLOTRONS, ISOTOPES, KINETICS, LIGHT NUCLEI, NUCLEI, NUCLEIC ACIDS, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, ORGANIC FLUORINE COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, PYRIMIDINES, RADIOISOTOPES, REACTION KINETICS, URACILS
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