[en] The elimination of intravenously administered Procarbazine-14C was studied in female weanling Yorkshire white pigs to determine the total percentage of such a dose eliminated in the urine. Maximum elimination of 74% was seen after 48 hours. This elimination percentage was then utilized to determine the amount of Procarbazine-14C absorbed after topical application of the drug. After 48 hours approximately 1% of a topically applied dose was absorbed through the test animals. Blood and tissue levels were also measured at 6, 24, and 4, 24, and 48 hours and in most cases showed negligible accumulation. Exceptions were the random samples of bone, fat, and abdominal skin which repeatedly showed significant levels of radioactivity. A significant percentage of the applied dose was generally detected at the application site after sacrifice