[en] The elimination of intravenously administered 14C-Cytosine-Arabinoside (Ara-C) was studied in female, weanling, Yorkshire white pigs to determine the total percentage of such a dose eliminated in the urine. Eighty-three percent of the dose was eliminated after 72 hours. This elimination percentage was then utilized to determine the amount of 14C-Ara C absorbed after topical application of the drug. After 48 hours, approximately 0.4% of the topically applied dose was absorbed through the skin of the test animals. Most tissue levels were not significant. However, fat at 6 hours and bone at 48 hours had high specific activity levels of radioactivity. Adrenals showed the only significant uptake in the whole organs assayed. A significant percentage of the applied dose was generally detected at and around the site of application