[en] Results of a detailed geochemical survey of part of the eastern flank of the Laramie Range and the northwestern edge of the Denver Basin in southeastern Wyoming are reported. Field and laboratory data are presented for 163 groundwater and 800 stream sediment samples, and field radiometric data are presented for 103 rock samples. Statistical and areal distributions of uranium and possible uranium-related variables are displayed. A generalized geologic map of the survey area is provided, and pertinent geologic factors which may be of significance in evaluating the potential for uranium mineralization, are briefly discussed. Two general trends of high uranium values are indicated by groundwater analysis: one running north-northeast to south-southwest through the center of the survey area, the other occurring in the southeastern corner of the survey area. The uranium trends are both underlain predominantly by waters of the Miocene and Oligocene rocks, and are separated by an area with anomalous concentrations of potassium and silicon. Stream sediment data indicate that soluble uranium (U-FL) is highest in the Precambrian igneous and metamorphic rocks in the western portion of the survey area, with the highest 85th percentile values occurring in granites, with gneisses closely following