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Bice, D.E.; Harris, D.L.; Muggenburg, B.A.; Bowen, J.A.
Inhalation Toxicology Research Institute. Annual report, October 1, 1979-September 30, 19801980
Inhalation Toxicology Research Institute. Annual report, October 1, 1979-September 30, 19801980
AbstractAbstract
[en] The effects of inhaled pollutants on the immune defenses in the lung can be studied in several animal species. To assure that the data obtained can be extrapolated to man, it is essential that the development of lung immunity is similar in the experimental animal selected and in humans. Because of the similarity of immune responses in chimpanzees and in humans, the development of immunity in the chimpanzee after lung immunization was evaluated. The results from the chimpanzees were qualitatively the same as those from previous studies in which single lung lobes of dogs were immunized. It was concluded that immunotoxicology data obtained in dogs can be used to estimate the effects of inhaled pollutants on the immune defense mechanism in the human lung
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Diel, J.H.; Bice, D.E.; Martinez, B.S. (eds.); Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (USA); p. 162-164; Dec 1980; p. 162-164
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