[en] Oral administration of 1,3-dibromopropane (2 mmol/kg) to rats resulted in a marked decrease in the level of hepatic glutathione (GSH). Sulphur-containing [¹⁴C]metabolites were excreted in the bile of rats dosed with 1,3-bromo[¹⁴C]propane and were subjected to enterohepatic cycling. After an oral dose of 1,3-dibromo[¹⁴C]propane, peak levels of radioactivity were rapidly attained in the blood and were maintanied for several hours; approximately equal amounts of radioactive material were excreted in urine and expired air. Several radioactive metabolites were excreted in urine; a major metabolite was N-acetyl-S-[1-bromo-3-propyl]-cysteine. (Auth.)