Filters
Results 1 - 1 of 1
Results 1 - 1 of 1.
Search took: 0.018 seconds
AbstractAbstract
[en] Total lymphoid irradiation (TLI) is a method which delivers irradiation daily in fractionated doses (200 rads) to lymphoid organs while shielding bones, lungs, and the majority of the gastrointestinal tract. TLI is lymphocytopenic in mice, rats, dogs, and humans, and both T cells and B cells are eliminated from the circulation. TLI permits establishment of specific and long-lasting tolerance to alloantigens. Permanent acceptance of allogeneic bone marrow cells without graft-versus-host disease was achieved in rats and dogs across major histocompatibility barriers. Recipients were tolerant to allografts of skin, hearts, and kidney from animals syngeneic to marrow donors or to organs from the marrow donor. This approach may be suitable for pancreas transplantation in diabetes
Primary Subject
Record Type
Journal Article
Journal
Diabetes; ISSN 0012-1797;
; v. 29 p. 121-123

Country of publication
ANIMAL CELLS, ANIMALS, BIOLOGICAL EFFECTS, BIOLOGICAL MATERIALS, BLOOD, BLOOD CELLS, BODY, BODY FLUIDS, CARDIOVASCULAR SYSTEM, CONNECTIVE TISSUE CELLS, DISEASES, EXTERNAL IRRADIATION, HEMIC DISEASES, IRRADIATION, LEUKOCYTES, LEUKOPENIA, LYMPHATIC SYSTEM, MAMMALS, ORGANS, PATHOLOGICAL CHANGES, PRIMATES, RADIATION EFFECTS, RODENTS, SOMATIC CELLS, SYMPTOMS, TRANSPLANTS, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue