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AbstractAbstract
[en] A method for the synthesis of C-11 iodoantipyrine was developed. Carbon-11-labeled methyl iodide, prepared from 11CO2, was used to methylate 3-methyl-1-phenyl-2-pyrazolin-5-one to form C-11 antipyrine. Preliminary animal studies showed complete cerebral extraction and local cerebral blood-flow values that were within 4.6% of those obtained using C-14 iodoantipyrine. The C-11 analog, with positron emission tomography, will facilitate local cerebral blood-flow studies in human subjects
Original Title
Rats
Source
28. Society of Nuclear Medicine annual meeting; Las Vegas, NV, USA; 16 Jun 1981
Record Type
Journal Article
Literature Type
Conference
Journal
Journal of Nuclear Medicine; ISSN 0022-3123;
; v. 22(6); p. 538-541

Country of publication
ANIMALS, AZOLES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, BRAIN, CARBON ISOTOPES, CENTRAL NERVOUS SYSTEM, CHEMICAL REACTIONS, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DRUGS, EMISSION COMPUTED TOMOGRAPHY, EVEN-ODD NUCLEI, HALOGENATION, HETEROCYCLIC COMPOUNDS, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, MAMMALS, MINUTES LIVING RADIOISOTOPES, NERVOUS SYSTEM, NUCLEI, ORGANIC COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANS, PYRAZOLES, RADIOACTIVE MATERIALS, RADIOISOTOPES, RODENTS, SYNTHESIS, TOMOGRAPHY, VERTEBRATES
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