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Ratib, O.; Phelps, M.E.; Huang, S.C.; Henze, E.; Selin, C.E.; Schelbert, H.R.
California Univ., Los Angeles (USA). Lab. of Biomedical and Environmental Sciences1981
California Univ., Los Angeles (USA). Lab. of Biomedical and Environmental Sciences1981
AbstractAbstract
[en] The deoxyglucose method originally developed for measurements of the local cerebral metabolic rate for glucose has been investigated in terms of its application to studies of the heart with positron computed tomography (PCT) and FDG. Studies were performed in dogs to measure the tissue kinetics of FDG with PCT and by direct arterial-venous sampling. The operational equation developed in our laboratory as an extension of the Sokoloff model was used to analyze the data. The FDG method accurately predicted the true MMRGlc even when the glucose metabolic rate was normal but myocardial blood flow (MBF) was elevated 5 times the control value or when metabolism was reduced to 10% of normal and MBF increased 5 times normal. Improvements in PCT resolution are required to improve the accuracy of the estimates of the rate constants and the MMRGlc
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1981; 23 p; Available from NTIS., PC A02/MF A01
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Report
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ALDEHYDES, ANIMALS, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, CARBOHYDRATES, CARDIOVASCULAR SYSTEM, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, EMISSION COMPUTED TOMOGRAPHY, FLUORINE ISOTOPES, HEART, HEXOSES, HOURS LIVING RADIOISOTOPES, ISOTOPES, LIGHT NUCLEI, MAMMALS, MONOSACCHARIDES, MUSCLES, NUCLEI, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, ORGANS, RADIOISOTOPES, SACCHARIDES, TOMOGRAPHY, VERTEBRATES
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