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AbstractAbstract
[en] The purpose of this projet is to determine the dose-response curve for lung-tumor incidence in rats following inhalation of 239PuO2 at levels producing a lifespan radiation dose of 2 to 100 rad. In preliminary studies, rats were intratracheally instilled with, or inhaled 169Yb-239PuO2 or 169Yb-Yb2O3 particles. Whole-body, excreta and tissue levels of 169Yb were determined by external gamma counting; 239Pu levels were determined radiochemically by scintillation counting. It was found that 169Yb dissociated from 239PuO2 and was cleared more rapidly from the lung and the whole body. Despite this fact, however, whole-body counts performed at 7 days after exposure to 169Yb-239PuO2 gave a reproducible measure of the 239Pu lung burden
Original Title
Rats
Primary Subject
Source
Drucker, H.; Pacific Northwest Lab., Richland, WA (USA); p. 89-91; Feb 1982; p. 89-91; Available from NTIS., PC A10/MF A01 as DE82011457
Record Type
Report
Report Number
Country of publication
ACTINIDE COMPOUNDS, ACTINIDE NUCLEI, ALPHA DECAY RADIOISOTOPES, ANIMALS, BETA DECAY RADIOISOTOPES, BIOLOGICAL EFFECTS, BIOLOGICAL RADIATION EFFECTS, BODY, CHALCOGENIDES, CLEARANCE, DAYS LIVING RADIOISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, EVEN-ODD NUCLEI, EXCRETION, HEAVY NUCLEI, INTAKE, INTERMEDIATE MASS NUCLEI, IRRADIATION, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, KINETICS, MAMMALS, MINUTES LIVING RADIOISOTOPES, NUCLEI, ORGANS, OXIDES, OXYGEN COMPOUNDS, PLUTONIUM COMPOUNDS, PLUTONIUM ISOTOPES, PLUTONIUM OXIDES, RADIOISOTOPES, RARE EARTH COMPOUNDS, RARE EARTH NUCLEI, RESPIRATORY SYSTEM, RODENTS, TRANSURANIUM COMPOUNDS, VERTEBRATES, YEARS LIVING RADIOISOTOPES, YTTERBIUM COMPOUNDS, YTTERBIUM ISOTOPES
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