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AbstractAbstract
[en] Progress was made in which ranges from picosecond measurements of quasifree-electron kinetics in model liquids to radiation-induced mutagenicity and lethality in a living system. The common thread that ties these seemingly disparate studies together is the electron which we exploit to probe the physico-chemical properties of model liquids in order to further our understanding of the role that this fundamental reducing species plays in biological processes. These studies are summarized. They are: (1) the effect of an electric field on the electron-attachment process in molecular liquids in order to determine how the rate of electron attachment is spatially dependent upon the distance from the parent ion; (2) the dependence of the electron-attachment process on the composition of the solvent in order to determine how the electron-attachment rate is influenced by the electron-transport mechanism of the medium; (3) the dependence of the electron-attachment rate on the dipole moment of the electron acceptor in order to determine the influence of electron-dipole interaction on the attachment mechanism; the electron-attachment properties of organized polymolecular aggregates in order to understand the electron-attachment process in a biomimetic microenvironment; (5) the electron-attachment properties of carcinogens in order to determine the role of electrophilicity in the initiating step of the carcinogenesis process; and (6) the mutagenic and lethal effects of ionizing radiation on the biological system that is most widely used to detect mutagens in order to determine if the DNA-strand-break mechanism can be elucidated with sufficient clarity to reveal the role that electrons play in DNA-electrophile interactions
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Source
30 Jun 1983; 31 p; Available from NTIS, PC A03/MF A01 as DE83014652
Record Type
Report
Literature Type
Progress Report
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INIS VolumeINIS Volume
INIS IssueINIS Issue