[en] This Safety Evaluation Report for the application filed by the Iowa State University (ISU) for a renewal of the Class 104 Operating License R-59 to continue to operate its Argonaut-type research reactor has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is owned and operated by the Iowa State University, and is located on the ISU campus in Ames, Story County, Iowa. The staff concludes that the reactor facility can continue to be operated by ISU without endangering the health and safety of the public. The principal matters reviewed are: design, testing, and performance of the reactor components and systems; the expected consequences of credible accidents; the licensee's management organization; the method used for the control of radiological effluents; the licensee's technical specifications; financial data and information; the physical protection program; procedures for training reactor operators; and emergency plans. 11 references, 15 figures, 13 tables