[en] The radiosensitizing effect of misonidazole was studied experimentally and clinically. Satisfactory radiosensitizing effect was observed in an experimental system using intracranially transplanted 203-glioma in C57BL mice. Then misonidazole was given orally to 27 patients with brain tumors as a clinical trial. In the next step, local administration of misonidazole pellet was studied in order to increase the intratumoral concentration of misonidazole. Constant release of misonidazole from the pellet was observed in both in vitro and in vivo experiments. As a clinical application of misonidazole pellet, 3 patients with brain tumors have been treated by local administration of misonidazole pellet into the tumor bed as an adjunct to radiotherapy. (author)