[en] Materials for heat exchangers in the high temperature gas-cooled reactor (HTGR) are subjected to cyclic loading, extending the necessity to design against fatigue failure into the temperature region where creep processes become significant. Therefore, the fatigue life must be considered in terms of creep-fatigue interaction. The HTGR-SC/C steam generator, a once-through type, is comprised of an economizer-evaporator-superheater (ESS) helical bundle of 2-1/4 Cr-1 Mo tubes followed by a superheater of straight tubes of Alloy 800H in the central zone of the steam generator. The high-temperature components affected by creep-fatigue interaction are the tubing and the superheated steam tubesheet of Alloy 800H. The effects of the revised creep-fatigue damage relationships were evaluated by: (1) calculating the temperature-dependent allowable strain range with the assumed bilinear damage relationship for Alloy 800H; (2) calculating the temperature-dependent allowable strain range with reduced fatigue allowables for 2-1/4 Cr-1 Mo; and (3) predicting the strain range in the critical parts by extrapolation of finite element calculations for the second or last cycle analyzed for each transient to the expected number of cycles and hold times