[en] For safety and economic reasons, the scope for carrying out experiments on operational nuclear power plants (NPPs) is very limited and any changes in technical equipment and operating parameters or conditions have to be supported by theoretical calculations. In the Nuclear Power Plant Scientific Research Institute (NIIAEhS), computer codes are systematically used to analyse actual operating events, assess safety aspects of changes in equipment and operating conditions, optimize the conditions, preparation and analysis of NPP startup trials and review and amend operating instructions. In addition, calculation codes are gradually being introduced into power plant computer systems to perform real time processing of the parameters being measured. The paper describes a number of specific examples of the use of calculation codes for the thermohydraulic analysis of operating and accident conditions aimed at improving the operation of WWER-440 units at the Jaslovske Bohunice V-1 and V-2 nuclear power plants. These examples confirm that computer calculations are an effective way of solving operating problems and of further increasing the level of safety and economic efficiency of NPP operation. (author)