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Arnett, C.D.; Fowler, J.S.; Wolf, A.P.; Shiue, C.Y.; Logan, J.
Brookhaven National Lab., Upton, NY (USA)1985
Brookhaven National Lab., Upton, NY (USA)1985
AbstractAbstract
[en] A series of 18F-labeled butyrophenones (benperidol, haloperidol, spiroperidol and N-methylspiroperidol) were evaluated in baboons and rats with respect to potential utility as radioligands for studying neuroleptic receptors in the living human brain by positron emission tomography. These compounds were administered to baboons, and the radioactivity distributions to the striatum, and to the cerebellum were determined by PET at times up to 8 hours after isotope injection. 4 refs. (DT)
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1985; 2 p; 12. international symposium on cerebral blood flow and metabolism; Lund (Sweden); 16-20 Jun 1985; CONF-8506187--1; Available from NTIS, PC A02; 3 as DE85017516
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Report
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Conference
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ANIMALS, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, BRAIN, CENTRAL NERVOUS SYSTEM, CENTRAL NERVOUS SYSTEM AGENTS, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DRUGS, EMISSION COMPUTED TOMOGRAPHY, FLUORINE ISOTOPES, HOURS LIVING RADIOISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, LIGHT NUCLEI, MAMMALS, NERVOUS SYSTEM, NUCLEI, ODD-ODD NUCLEI, ORGANS, PRIMATES, PSYCHOTROPIC DRUGS, RADIOISOTOPES, RODENTS, TOMOGRAPHY, VERTEBRATES
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