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Knapp, F.F. Jr.; Goodman, M.M.; Machulla, H.J.; Knust, E.J.; Kartje, M.; Vyska, K.
Oak Ridge National Lab., TN (USA); Essen Univ. (Gesamthochschule) (Germany, F.R.)1986
Oak Ridge National Lab., TN (USA); Essen Univ. (Gesamthochschule) (Germany, F.R.)1986
AbstractAbstract
[en] For studying the pharmacokinetic behaviour of fatty acids with different chemical structures four 123I-labelled compounds, i.e., the ortho and para 123I-isomers of 15-phenylpentadecanoic acid (IPPA) and 3-methyl-15-phenylpentadecanoic acid were prepared and the organ distribution determined in mice. The results show a significant decrease of the maximal heart uptake for the two ortho compounds. Further, the hypothesis of a blocked metabolism as an effect of the β-methylation could not be confirmed. Both β-methylated compounds show a biexponential elimination behavior from the heart. 5 refs., 2 figs
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1986; 7 p; International symposium on radioactive isotopes in clinical medicine and research; Badgastein (Austria); 13-16 Jan 1986; Available from NTIS, PC A02/MF A01 as DE86005084
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