[en] This Safety Guide provides requirements and recommendations for the establishment and implementation of a quality assurance programme for activities important to safety during the commissioning, operation and decommissioning phases of a nuclear power plant. It applies to activities such as: the commissioning, inspecting, testing, operating, refuelling, maintaining, repairing, modifying and eventually shutting down and decommissioning of nuclear power plants. It also applies to associated activities related to safety, such as radiation protection, environmental monitoring, handling of radioactive wastes, responses to emergencies and physical security