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AbstractAbstract
[en] In this thesis it is examined if by hormonal suppression of spermatogenesis the disadvantageous side-effects of radiation therapy on the gonads can be reduced. Therefore a rat model was investigated, where hormonal suppression of spermatogenesis during irradiation was achieved and stem cell survival was measured. Attention was focussed on the stem cell, because this cell is primarily responsible for the late effects of radiation on fertility. Flow cytometrical and histological techniques were used as parameters for measuring stem cell survival. Serum concentrations of FSH, LH and testosterone were measured to evaluate the hormonal suppression. (Auth.)
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16 Oct 1986; 139 p; Includes Dutch summary and previously published material; 385 refs.; 29 figs.; Proefschrift (Dr.).
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Miscellaneous
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Thesis/Dissertation
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