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AbstractAbstract
[en] Experiments have now been completed designed to investigate the RBE for the induction of mutations in human cells by low dose-rate exposure to Pu-Be neutrons. Continuous exposure of human lymphoblastoid cells over periods of 5 to 20 days resulted in a markedly enhanced mutation frequency at two genetic loci overthat observed when comparable doses of neutrons were administered in a period of a few hours. Results are now available from a total of 148 thymidine kinase mutant clones induced by exposure to x-rays, fast neutrons or Argon-40 ions. The molecular structural of changes at the active tk allele were detected by the use of a SacI restriction fragment length polymorphism and Southern blotting. 1 ref
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Source
1987; 3 p; Available from NTIS, PC A02/MF A01; 1 as DE88007055; Portions of this document are illegible in microfiche products.
Record Type
Report
Literature Type
Progress Report
Report Number
Country of publication
AUGER EFFECT, BIOLOGICAL RADIATION EFFECTS, CELL CULTURES, DOSE RATES, GENE MUTATIONS, INTERNAL CONVERSION RADIOISOTO, IODINE 125, IODINE 131, LYMPHOCYTES, MUTAGENESIS, MUTATION FREQUENCY, NEUTRONS, PHOSPHOTRANSFERASES, PROGRESS REPORT, RADIATION DOSES, RADIOBIOLOGY, RBE, TRITIUM COMPOUNDS, X RADIATION
ANIMAL CELLS, BARYONS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BIOLOGICAL EFFECTS, BIOLOGICAL MATERIALS, BIOLOGY, BLOOD, BLOOD CELLS, BODY FLUIDS, CONNECTIVE TISSUE CELLS, DAYS LIVING RADIOISOTOPES, ELECTROMAGNETIC RADIATION, ELECTRON CAPTURE RADIOISOTOPES, ELEMENTARY PARTICLES, ENZYMES, FERMIONS, HADRONS, HYDROGEN COMPOUNDS, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, IONIZING RADIATIONS, ISOTOPES, LEUKOCYTES, MATERIALS, MUTATIONS, NUCLEI, NUCLEONS, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, PHOSPHORUS-GROUP TRANSFERASES, RADIATION EFFECTS, RADIATIONS, RADIOISOTOPES, SOMATIC CELLS, TRANSFERASES
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