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Muggenburg, B.A.; Boecker, B.B.; Hahn, F.F.; Griffith, W.G.; McClellan, R.O.
Life-span radiation effects studies in animals: What can they tell us: DOE symposium series 581986
Life-span radiation effects studies in animals: What can they tell us: DOE symposium series 581986
AbstractAbstract
[en] Life-span studies in progress using beagle dogs that inhaled relatively soluble or relatively insoluble forms of radionuclides will provide information from which we may project the risk to humans for liver cancer from inhaled radioactive material. Twenty-two liver tumors have been observed in dogs exposed to beta-emitting radionuclides, mainly 144Ce, and one liver tumor in a dog exposed to 238Pu. Two liver cancers were also observed in control dogs. The risk of liver cancer in dogs that inhaled beta-emitting radionuclides was calculated to be 90 liver cancers per million rads. The risk of liver cancers in dogs in our studies and in studies at the University of Utah, when compared to the incidence of liver tumors in humans exposed to Thorotrast, suggest that the risk of liver cancer from an inhaled beta-emitting radionuclide in people is about 30 liver cancers per million person-rads. 19 refs., 3 tabs
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Thompson, R.C.; Mahaffey, J.A. (eds.); Pacific Northwest Lab., Richland, WA (USA); p. 556-563; Oct 1986; p. 556-563; 22. Hanford life sciences symposium - life-span radiation effects studies in animals - what can they tell us; Richland, WA (USA); 27-29 Sep 1983; Available from NTIS, PC A99; 3 as TI87000490
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Report
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Conference
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BEAGLES, BETA DECAY RADIOISOTOPES, CARCINOMAS, CERIUM 144, CESIUM 137, EXTRAPOLATION, INHALATION, LIFE SPAN, LIVER, MAN, MORTALITY, PLUTONIUM 238, RADIATION EFFECTS, RADIOACTIVE AEROSOLS, RADIONUCLIDE KINETICS, RISK ASSESSMENT, SARCOMAS, SPONTANEOUS FISSION RADIOISOTO, STRONTIUM 90, SURVIVAL TIME, YTTRIUM 90, YTTRIUM 91
ACTINIDE NUCLEI, AEROSOLS, ALPHA DECAY RADIOISOTOPES, ANIMALS, BETA-MINUS DECAY RADIOISOTOPES, BODY, CERIUM ISOTOPES, CESIUM ISOTOPES, COLLOIDS, DAYS LIVING RADIOISOTOPES, DIGESTIVE SYSTEM, DISEASES, DISPERSIONS, DOGS, EVEN-EVEN NUCLEI, GLANDS, HEAVY NUCLEI, HOURS LIVING RADIOISOTOPES, INTAKE, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, KINETICS, MAMMALS, MINUTES LIVING RADIOISOTOPES, NEOPLASMS, NUCLEI, NUMERICAL SOLUTION, ODD-EVEN NUCLEI, ODD-ODD NUCLEI, ORGANS, PLUTONIUM ISOTOPES, PRIMATES, RADIOISOTOPES, RARE EARTH NUCLEI, SOLS, STRONTIUM ISOTOPES, VERTEBRATES, YEARS LIVING RADIOISOTOPES, YTTRIUM ISOTOPES
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