[en] A review is presented of heavy quark production in bar pp, π^-p, and pp interactions at fixed target and collider energies. Calculations of total cross sections and of single quark inclusive differential cross sections d²ω/dk_Tdy are described including contributions through next-to-leading order in QCD perturbation theory. Comparisons with available data on charm and bottom quark production show good agreement for reasonable values of the charm and bottom quark masses and other parameters. Predictions and open issues in the interpretation of results are summarized. A brief discussion is presented of signatures, backgrounds, and expected event rates for top quark production. 24 refs., 6 figs