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[en] The authors studied the activation of oncogenes in radiation-induced tumours of the respiratory tract obtained from beagles exposed by inhalation to plutonium-238 oxide or plutonium-239 oxide. Among eight tumours and several control samples examined, one case of tumour-related oncogene over-expression has been detected. This observation could mean that few genes or oncogene products are associated with plutonium-induced carcinogenesis of the lung. (author)
Source
Baverstock, K.F. (Medical Research Council, Harwell (UK). Radiobiological Research Unit); Stather, J.W. (National Radiological Protection Board, Chilton (UK)) (eds.); 620 p; ISBN 0-85066-746-1; 
; 1989; p. 286-295; Taylor and Francis; London (UK); 14. L.H. Gray conference; Oxford (UK); 11-15 Sep 1989; CONTRACT DE-AC04-76EV01013
; 1989; p. 286-295; Taylor and Francis; London (UK); 14. L.H. Gray conference; Oxford (UK); 11-15 Sep 1989; CONTRACT DE-AC04-76EV01013