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Sundell-Bergman, S.; Johanson, K.J.; Richter, S.
Workshop on photon activation therapy: proceedings1985
Workshop on photon activation therapy: proceedings1985
AbstractAbstract
[en] An investigation was made of the appearance of DNA damage and survival of IUdR-labelled CHO cells irradiated with gamma (sup 137 Cs) or soft X-rays (75 kV). The absorbed dose and radiation quality were measured using an ionization chamber and thermoluminescent dosemeter. Results show that there was a dose-dependent decrease in the survival of cells after irradiation with gamma or soft X-rays. In both cases the survival of IUdR-labelled cells was less than that of control cells. They yield of strand breaks increased linearly with doses up to a maximum of 6 Gy for gamma rays and 4 Gy for X-rays. After gamma irradiation the capacity of cells to repair DNA breaks was slower in IUdR-containing cells than in control cells. The potential of photon activation for improvement of radiotherapy is discussed
Primary Subject
Source
Fairchild, R.G. (ed.); Brookhaven National Lab., Upton, NY (USA); p. 25-34; 18 Apr 1985; p. 25-34; Workshop on photon activation therapy; Upton, NY (USA); 18 Apr 1985; Available from NTIS, PC A04/MF A01; 1 as DE86013672
Record Type
Report
Literature Type
Conference; Numerical Data
Report Number
Country of publication
AUGER EFFECT, CELL CULTURES, CESIUM 137, CHO CELLS, DNA, DNA REPAIR, DOSE-RESPONSE RELATIONSHIPS, EXPERIMENTAL DATA, IODODEOXYURIDINE, RADIATION EFFECTS, RADIATION QUALITY, RADIOACTIVATION, RADIOTHERAPY, SOFT X RADIATION, STRAND BREAKS, SURVIVAL CURVES, THERMOLUMINESCENT DOSEMETERS, UPTAKE, X-RAY DOSIMETRY
ANIMAL CELLS, ANTIMETABOLITES, AZINES, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BIOLOGICAL RECOVERY, BIOLOGICAL REPAIR, CESIUM ISOTOPES, DATA, DOSEMETERS, DOSIMETRY, DRUGS, ELECTROMAGNETIC RADIATION, HETEROCYCLIC COMPOUNDS, HYDROXY COMPOUNDS, INFORMATION, INTERMEDIATE MASS NUCLEI, IODOURACILS, IONIZING RADIATIONS, ISOTOPES, LUMINESCENT DOSEMETERS, MEASURING INSTRUMENTS, MEDICINE, NUCLEI, NUCLEIC ACIDS, NUCLEOSIDES, NUCLEOTIDES, NUMERICAL DATA, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC IODINE COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, PYRIMIDINES, RADIATIONS, RADIOISOTOPES, RIBOSIDES, SOMATIC CELLS, THERAPY, URACILS, X RADIATION, YEARS LIVING RADIOISOTOPES
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