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AbstractAbstract
[en] This progress report summarizes the research accomplished and its clinical implementation since July 15, 1989. To improve beta-particle dosimetry, a point-source function was developed that is valid for a wide range of beta-particle emitters. An analytical solution for beta-particle dose rates within and outside of slabs of finite thickness was validated in an experimental tumor system and is now being used in clinical radioimmunotherapy (RIT). Quantitative SPECT was validated in phantom studies, beagle dogs, and patients with Kaposi's sarcoma. It is currently being used in clinical RIT for patients with Hodgkin's disease or hepatoma. Additionally, methodologies and computer software are being developed for quantitative autoradiography to achieve absorbed-dose calculation on the cellular level. 7 refs., 1 tab
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Source
Feb 1990; 17 p; CONTRACT FG02-89ER60867; NTIS, PC A03/MF A01 as DE90007366; OSTI; INIS; US Govt. Printing Office Dep
Record Type
Report
Literature Type
Progress Report
Report Number
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ALGORITHMS, ANALYTICAL SOLUTION, AUTORADIOGRAPHY, BEAGLES, BETA DOSIMETRY, BETA PARTICLES, DOSE RATES, HEPATOMAS, HODGKINS DISEASE, IMMUNOTHERAPY, IMPLEMENTATION, INDIUM 111, INFORMATION DISSEMINATION, IODINE 131, LIVER, MAN, MICRODOSIMETRY, OPTIMIZATION, PHANTOMS, PROGRESS REPORT, RADIOTHERAPY, RESEARCH PROGRAMS, S CODES, SARCOMAS, YTTRIUM 90
ANIMALS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, CHARGED PARTICLES, COMPUTER CODES, DAYS LIVING RADIOISOTOPES, DIGESTIVE SYSTEM, DISEASES, DOGS, DOSIMETRY, ELECTRON CAPTURE RADIOISOTOPES, GLANDS, HOURS LIVING RADIOISOTOPES, INDIUM ISOTOPES, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, IONIZING RADIATIONS, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LYMPHOMAS, MAMMALS, MEDICINE, MINUTES LIVING RADIOISOTOPES, MOCKUP, NEOPLASMS, NUCLEI, ODD-EVEN NUCLEI, ODD-ODD NUCLEI, ORGANS, PRIMATES, RADIATIONS, RADIOISOTOPES, STRUCTURAL MODELS, THERAPY, VERTEBRATES, YTTRIUM ISOTOPES
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