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AbstractAbstract
[en] A radioprotective combination 'anthopyrrole' consisted of 20 mg/kg alpha tocopherol (water-soluble form of BASF), 50 mg/kg anthocyans (powder) and 200 mg/kg pyracetam was administered orally 2x5 days on adult male ICR mice. Irradiation from a 137Cs source was performed 48 hrs after the last administration. The radioprotective potential of the mixture and of each of its components solely against lethal irradiation of 8 Gy=LD95/30 was assessed by recording the integral measures of 30-day survival rate and mean survival time of succumbing animals. The influence of the mixture on blood formation was studied for a sublethal irradiation of 6 Gy. At postradiation days 3 and 10 records were made on changes in spleen weight and cellularity, and in femoral bone-marrow karyocyte counts. It was found that the pretreatment with the mixture distinctly raised survival rate (50%) in the protected population. The effect observed was shown to result from potentiating interactions between mixture components. Blood-forming organs experienced less radiation damage and recovery process in them were stimulated. 3 figs., 14 refs
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