[en] The studies were performed in three experimental setups after single and repeated (5, 10, 20 and 30 times daily) application of dopamine agonists and antagonists (levodopa, bromcryptine, apomorphine hydrochloride, levodopa + carbidopa combination and haloperidol) for determining the changes in the serum ACTH level in rats. In stress-free conditions and in the presence of stress effects dopamine agonists were shown to exert inhibiting effect on ACTH release. The independent role of the brain dopaminergic system was studied on combined application of agents (obsidan, phentolamine and piperoxan) blocking the central alpha- and beta-receptors and dopamine agonists and antagonists, accordingly under stress-free conditions and after cold-induced stress. The results pointed out the participation of the dopaminergic system in the complex neuro-meditary mechanism of controlling the production and release of ACTH from the adenohypophysis both under stress-free and stress conditions. A hypothesis is advanced that the brain dopaminergic system is implicated in the regulation of the adrenocorticotropic function in suppressed adrenergic system. 3 figs, 7 refs