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AbstractAbstract
[en] A total of sixty-six rats were included in a study on radioimmunodetection. During these experiments, attempts were made on the basis of five different methods were used in an attempt to detect the injected antibodies. These were scintigraphy, flow measurements, activity determinations in both the intracellular and extracellular spaces, autoradiogrammes and PaP staining. The use of a range of various methods of detection turned out to be very advantageous, as the successful visualisation of the tumours in the scintigrammes and their marked activity concentrations of might have been interpreted as an indication of specific binding of anti-TPA to the tumour grafts. The absence of any such specific reactions was, however, quite obvious from the fact that TPA could not be detected in the tumour models used for the same purpose. (orig./MG)
[de]
Insgesamt wurden an sechsundsechzig Ratten Versuche zur Radioimmunodetection durchgefuehrt. Dabei versuchte man die injizierten Antikoerper mit fuenf verschiedenen Methoden nachzuweisen: Szintigraphisch, durch Flowmessungen, durch Aktivitaetsbestimmungen im Intra- und Extrazellulaerraum, durch Autoradiographie und PaP-Faerbung. Diese Vielzahl an Nachweismethoden hat sich als guenstig erwiesen, da man aufgrund der gelungenen szintigraphischen Tumordarstellungen und der starken Aktivitaetsanreicherung im Tumor zu dem Schluss haette kommen koennen, dass sich anti-TPA spezifisch an die Tumortransplantate anlagert. Dass diese Anlagerung aber nicht spezifisch sein kann, ergibt sich daraus, dass TPA in den verwendeten Tumormodellen nicht nachgewiesen werden konnte. (orig./MG)Original Title
Radioimmunodetection mit anti-TPA*J125 bei SD-Ratten mit Walker-Carcinosarkom und ACI-Ratten mit Blasencarcinom
Primary Subject
Secondary Subject
Source
21 Jan 1988; 135 p; Available from the library of Bonn Univ. (Germany); Diss. (Dr.med.).
Record Type
Miscellaneous
Literature Type
Thesis/Dissertation
Country of publication
ANIMALS, BETA DECAY RADIOISOTOPES, COUNTING TECHNIQUES, DAYS LIVING RADIOISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, IMMUNOASSAY, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, MAMMALS, NEOPLASMS, NUCLEI, ODD-EVEN NUCLEI, RADIOISOTOPE SCANNING, RADIOISOTOPES, RODENTS, TRACER TECHNIQUES, VERTEBRATES
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