[en] The production of large quantities of high specific activity ⁶³Ni (>10Ci/g) requires both a highly enriched ⁶²Ni target and a long irradiation period at high neutron flux. Trace impurities in the nickel and associated target materials are also activated and account for a significant fraction of the discharged activity and essentially all of the gamma activity. While most of these undesirable activation products (mainly transition metals) can be easily removed as chloride complexes during anion exchange, chromium, present as ⁵¹Cr, and manganese, present as ⁵⁴Mn, are exceptions and require solvent extraction of the in-cell product to achieve the desired purity. In addition to summarizing the current development and production experience, optimized flowsheets are discussed