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Brugger, R.M.; Liu, H.B.; Laster, B.H.; Gordon, C.R.; Greenberg, D.D.; Warkentien, L.S.
Brookhaven National Lab., Upton, NY (United States). Funding organisation: USDOE, Washington, DC (United States)1992
Brookhaven National Lab., Upton, NY (United States). Funding organisation: USDOE, Washington, DC (United States)1992
AbstractAbstract
[en] At BNL, preparations are being made to test in vitro compounds containing Gd and compare their response to the response of GD-DTPA to determine if one or several compounds can be located that enter the cells and enhance the Auger effect. Two similar rotators with positions for cell vials that have been constructed for these tests. The first rotator is made of only paraffin which simulates healthy tissue and provides control curves. The second rotator has 135 ppM of Gd-157 in the paraffin to simulate a Gd loaded tumor. Cells are irradiated in vials in the paraffin rotator and in the Gd-paraffin rotator at the epithermal beam of the Brookhaven Medical Research Reactor (BMRR). This produces an irradiation similar to what a patient would receive In an actual treatment. A combination of irradiations are made with both rotators; with no Gd compound or IdUrd In the cell media, with only Gd compound in the cell media and with both Gd compound and IdUrd in the cell media. The first set shows the effects of gamma rays from the H(n,gamma) reaction and the prompt gamma rays from capture of neutrons by Gd. The second set shows if there is any effect of Gd being in the cell media or inside the cells, i.e., an Auger effect. The third set shows the effect of enhancement by the IdUrd produced by the gamma rays from neutrons captured by either H or Gd. The fourth set combines all of the reactions and enhancements. Preliminary calculations and physical measurements of the doses that the cells will receive In these rotators have been made
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1992; 7 p; Neutron capture therapy for cancer; Columbus, OH (United States); 13-17 Sep 1992; CONF-9209280--5; CONTRACT AC02-76CH00016; OSTI as DE93005591; NTIS; INIS; US Govt. Printing Office Dep
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Report
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Conference
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AMINO ACIDS, BARYONS, CARBOXYLIC ACIDS, CHELATING AGENTS, DRUGS, ELEMENTARY PARTICLES, EVEN-ODD NUCLEI, FERMIONS, GADOLINIUM ISOTOPES, HADRONS, INTERMEDIATE MASS NUCLEI, ISOTOPES, LABELLED COMPOUNDS, MATERIALS, MEDICINE, NEUTRON THERAPY, NEUTRONS, NUCLEI, NUCLEONS, ORGANIC ACIDS, ORGANIC COMPOUNDS, RADIOACTIVE MATERIALS, RADIOPROTECTIVE SUBSTANCES, RADIOTHERAPY, RARE EARTH COMPOUNDS, RARE EARTH NUCLEI, RESPONSE MODIFYING FACTORS, STABLE ISOTOPES, THERAPY
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