[en] The present study evaluates the action of vitamin E and urea as chemical radioprotectors for controlling the radiation induced changes in creatine and creatinine levels in the forebrain of female rats subjected to 7 Gy whole body gamma irradiation. The levels of creating and creatinine in the forebrain of normal control rats were±704±22 to±724±23 and 11.053 0.119 to 11.553 0.127 /g fresh tissue; respectively. The applied radiation dose caused a significant increase in the creating level of about 15%, 18%, 13% and 41% on the first,third,seventh and tenth days post irradiation; respectively. At the same post irradiation days, the level of creatinine generally increased, but not to the same extent as creatine. The treatment of rats either with vitamin E or with urea pre radiation exposure caused a remarkable recovery in both creatine and creatinine levels in the forebrain of irradiated rats.The results are discussed in the high of discussed in the high of available literatures. 2 tab