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AbstractAbstract
[en] Radioimmunoimaging characteristics of a new monoclonal antibody EBA-1 and its F(ab')2 fragments utilizing nu/nu mice bearing human breast carcinoma xenografts are described. 111In-DPTA conjugates of EBA-1 localized with tumor/blood ratios of 0.99 ± 0.10 (P < 0.3) and 4.65 ± 1.60 (P < 0.05), and localization indices of 1.25 and 2.61 at 24 and 72 h, respectively. A tumor/blood ratio as high as 28.86 ±6.90 (P < 0.025) was obtained with EBA-1 F(ab')2 radioconjugates at 48 h. These results suggest that EBA-1 and its F(ab')2 might be useful reagents in radioimmunoimaging and radioimmunotherapy. (author)
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ANIMALS, ANTIBODIES, BETA DECAY RADIOISOTOPES, BODY, DAYS LIVING RADIOISOTOPES, DIAGNOSTIC TECHNIQUES, DISEASES, DRUGS, ELECTRON CAPTURE RADIOISOTOPES, GLANDS, INDIUM ISOTOPES, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPE APPLICATIONS, ISOTOPES, LABELLED COMPOUNDS, MAMMALS, MATERIALS, MINUTES LIVING RADIOISOTOPES, NEOPLASMS, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIOACTIVE MATERIALS, RADIOASSAY, RADIOISOTOPES, RODENTS, TRACER TECHNIQUES, TRANSPLANTS, VERTEBRATES
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