[en] Application of Fourier transform methods in Nuclear Magnetic Resonance (NMR) studies has not only revolutionized the capabilities of NMR to study structure, dynamics and reactions of complex molecules in vitro, but has also provided an opportunity for non-invasive studies of complex biochemistry in vivo. This paper provides an insight into modern pulse NMR techniques and understanding of fundamental physical principles in designing various modern spin echo, polarization transfer and multi quantum coherence pulse sequences in high resolution NMR spectroscopy. Special reference is given to modern two dimensional techniques which have resulted in a major development in high resolution NMR spectroscopy during the last decade. (author)