[en] From August 1989 to October 1992, a total of 27 patients with breast cancer of stage II received breast-conservation treatment (BCT) intensified with systemic chemotherapy and endocrine therapy. All these patients visited the out-patient clinic of the Department of Radiology of Kochi Medical School Hospital, with an obvious desire of undertaking BCT. During this period, another two patients with the same desire were treated with modified radical mastectomy because of obviously positive surgical margins in frozen sections obtained at surgery. The percentage of patients treated by BCT was, therefore, 93.1%. These were all females, and their average age was 50.9 years. Twenty-five out of these 27 patients underwent lumpectomy, and another 2 patients with suspected extensive intraductal component were performed quadrantectomy. Eleven of these 27 patients, who were over 70 years old or had no clinical detectable axillary lymph node swelling received tangential field radiotherapy to their ipsilateral axillary region instead of axillary dissection. For n0 or nX cases, radiotherapy was delivered using opposed tangential fields alone, and for n1 cases tangential fields and irradiation to the ipsilateral axillary and supraclavicular regions were administered. After the radiotherapy, systemic chemotherapy was performed intravenously using cyclophosphamide, pirarubicin and 5-fluorouracil. As an endocrine therapy, tamoxifen was routinely administered at a dose of 20-40 mg/day. By the end of February 1993, 1out of these 27 patients had died of the progression of distant metastases of breast cancer to bone, liver, lung and brain. And another one had died of pneumonia with no evidence of breast cancer progression. Therefore, cause-specific survival rates were 100% (21/21), 91.7% (11/12) and 83.3% (5/6), at 1, 2 and 3 years, respectively. As for side effects of the theraphy, no severe sequelae has been experienced. Cosmetic results of the theraphy were considerably good. (author)