[en] ¹⁷O NMR spectroscopy has become a powerful method for the solution of structural problems in organic chemistry, mainly through the availability of modern high field NMR equipment. Nevertheless the experimental problems are the limiting factors for a general use of this method. Therefore 90% of the literature on oxygen-17 NMR are dealing with small molecules up to 250 dalton. One aim of this work was to extend the application to larger molecules. Using linear prediction and maximum entropy methods for dataprocessing it was possible to get high quality ¹⁷O NMR spectra of molecules in the range of 300 to 500 dalton. The main systems under investigation were tricyclic diterpen derivatives and a large series of steroids. From a careful analysis of the chemical shiftvalues of the various oxygen containing functional groups located in different ring positions it was possible to answer configurational assignment questions. In some cases the structural information can be obtained faster and easier by ¹⁷O NMR than by conventional ¹H and ¹³C NMR techniques. Another task was the comparison of structural information from x-ray analysis data taken from the literature with ¹⁷O resonances within the class of spirophosphoranes. Changes in the geometry at the pentacoordinated phosphorus due to different substituents can be studied. The application of this NMR technique to constitutional problems of organic molecules is shown in the last part of this work. It was easily possible to distinguish between different isomers using ¹⁷O NMR spectroscopy, which was shown by application of this newly implemented method to three structure elucidation problems