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[en] By means of RFLPs method, the alterations of hprt gene structure in the mutant CHO-K1 and HeLa MR cells induced by γ-exposure were examined in order to study the molecular mechanism of gene mutation induced by ionizing radiation; expression of hprt gene in CHO-K 1 mutant cells were also observed by Northern blot as well as slot blot. This experiment showed that ionizing radiation could result in hprt gene structure change which might lead to deficiency in mRNA transcription
Journal
Journal of Radiation Research and Radiation Processing; ISSN 1000-3436; 
; CODEN FYYXEA; v. 12(3); p. 164-168
; CODEN FYYXEA; v. 12(3); p. 164-168