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Wadabayashi, Nobutoshi; Ichihashi, Masamitsu; Honda, Chihiro; Mishima, Yutaka.
Basic and clinical researches for the development of neutron capture therapy1994
Basic and clinical researches for the development of neutron capture therapy1994
AbstractAbstract
[en] Malignant melanoma occurs not only in the skin but also in ocular tissues. Ocular melanoma located superficially as in conjunctiva can be treated successfully by BNCT. In the present study, we investigated 10B dynamics in ocular melanoma and the surrounding normal tissues, to evaluate the possibility of applying BNCT to ocular melanoma. In three ocular melanoma patients, 10B concentration in melanoma after administration of 10B-BPA by oral or drip infusion ranged from 10.4 to 21.5 ppm. The boron concentrations in lens and vitreous body were lower than blood level, whereas higher than blood in sclera and palpebral skin. These results suggest that we can treat such a superficial melanoma lesions as conjunctival melanoma by BNCT using 10B1-BPA. (author)
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Kikuchi, Haruhiko (ed.) (Kyoto Univ. (Japan). Faculty of Medicine); Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst; 162 p; Mar 1994; p. 57-66
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Report
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Country of publication
AMINO ACIDS, ANIMALS, BIOLOGICAL MATERIALS, BODY, BODY FLUIDS, BORON ISOTOPES, CARBOXYLIC ACIDS, CARCINOMAS, DISEASES, EPITHELIOMAS, ISOTOPES, LIGHT NUCLEI, MAMMALS, MAN, MATERIALS, MEDICINE, NEOPLASMS, NEUTRON THERAPY, NUCLEI, ODD-ODD NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANS, PRIMATES, RADIOTHERAPY, SENSE ORGANS, STABLE ISOTOPES, THERAPY, VERTEBRATES
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