[en] During the NRC's Short Cracks in Piping and Piping Welds Program at Battelle, a probabilistic methodology was developed to conduct fracture evaluations of circumferentially cracked pipes for application to leak-rate detection. Later, in the IPIRG-2 program, several parameters that may affect leak-before-break and other pipe flaw evaluations were identified. This paper presents new results from several uncertainty analyses to evaluate the effects of normal operating stresses, normal plus safe-shutdown earthquake stresses, off-centered cracks, restraint of pressure-induced bending, and dynamic and cyclic loading rates on the conditional failure probability of pipes. systems in BWR and PWR. For each parameter, the sensitivity to conditional probability of failure and hence, its importance on probabilistic leak-before-break evaluations were determined