[en] Works on creation and modification of classical and then isochronous cyclotron systems in the Inst. of Nuclear Physics of National Nuclear Center of Republic of Kazakstan are elucidated. It is emphasized, that cyclotron transference on isochronous regime with regulated energy of ions in 1972 made possible operative calculation of accelerated ions type and its energies. Increasing of protons' energy from 10 up 30 MeV has been permitted nuclear reaction of (A, 3 n) type. Making of cyclotron's new ramified system of external beam has been essentially increased of research efficiency. It is marked, that numerous of national importance programs is carried out on producing of radioactive isotopes. Introduction of operation of cascade recharge accelerator of heavy ions UKP-2-1 in 1989 permitted to conduct researches in field of solid state physics, atomic physics on beams of heavy ions, nuclear physics of low-nucleon physics, nuclear microanalysis and others. The complex for measuring-spectral analysis with proton excitation started its operation on UKP-2-1 in 1995. The method of nuclear reactions is mastered, and methodic of back Retherford scattering is adjusted as well