[en] Over the last decade Argonne National Laboratory has developed reactor depletion methods and models to determine radionuclide inventories of irradiated EBR-II fuels. Predicted masses based on these calculational methodologies have been validated using available data from destructive measurements--first from measurements of lead EBR-II experimental test assemblies and later using data obtained from processing irradiated EBR-II fuel assemblies in the Fuel Conditioning Facility. Details of these generic methodologies are described herein. Validation results demonstrate these methods meet the FCF operations and material control and accountancy requirements