[en] The main objective of this publication is to review the different options and provide practical guidance on the management of biomedical radioactive waste that may arise in health care facilities, clinics, laboratories and other associated medical institutions. It outlines the advanced practices used in different facilities around the world that handle radionuclides for biomedical applications and therefore deal with management of the associated waste. Biomedical radioactive waste management includes handling, packaging, treatment, conditioning, storage, transportation and disposal of the radioactive waste that is produced in medical facilities. When radioisotopes are to be used in a biomedical facility, proper consideration should be given to the design of the facility to ensure safe use of the material in accordance with the requirements of the regulatory organizations. Such consideration should include planning for processing, storage and disposal of all generated radioactive waste. While this publication is directed primarily to developing Member States, it also reflects the practices applied in countries with extensive nuclear programmes. Therefore this publication should be useful for any biomedical establishment dealing with medical applications of radioisotopes and consequently with the wastes associated with such applications