[en] The nuclear plants for desalination to be built in the future will have to meet the standards of safety required for the best nuclear power plants currently in operation or being designed. The current safety approach, based on the achievement of the fundamental safety functions and defence in depth strategy, has been shown to be a sound foundation for the safety and protection of public health, and gives the plant the capability of dealing with a large variety of sequences, even beyond the design basis. The Department of Nuclear Safety of the IAEA is involved in many activities, the most important of which are to establish safety standards, and to provide various safety services and technical knowledge in many Technical Co-operation assistance projects. The department is also involved in other safety areas, notably in the field of future reactors. The IAEA is carrying out a project on the safety of new generation reactors, including those used for desalination, with the objective of fostering an exchange of information on safety approaches, promoting harmonization among Member States and contributing towards the development and revision of safety standards and guidelines for nuclear power plant design. The safety, regulatory and environmental concerns in nuclear powered desalination are those related directly to nuclear power plants, with due consideration given to the coupling process. The protection of product water against radioactive contamination must be ensured. An effective infrastructure, including appropriate training, a legal framework and regulatory regime, is a prerequisite to considering use of nuclear power for desalination plants, also in those countries with limited industrial infrastructures and little experience in nuclear technology or safety. (author)