[en] A simple synthesis method of ¹⁸F-fluoroethylspiperone in exchange for ¹¹C-methylspiperone, diagnostics of Parkinson's disease, was developed and an automatic synthetic reactor was made. Spiperone and ¹⁸F-CH₂CH₂-OTs synthesized ¹⁸F-fluoroethylspiperone. Reagents were supplied by products on the market. The automatic reactor is consisted of two units such as a turntable type reactor and HPLC operated by computer control. The parameters (temperature, time and pressure, etc.) are set by input. The amount of reagents can be determined at will. The radiochemical yield was about 15% that were less than 30% of hand-operated reactor. The main cause is evaporation of ¹⁸F-CH₂CH₂-OTs. (S.Y.)