[en] The production of reference manual of procedures for distribution to laboratories engaged in shellfish toxicity research and monitoring activities and this manual is a contribution to the regional project which was funded by the Philippine Department of Science and Technology and produced by the Philippine Nuclear Research Institute. The main objectives of the project are the transfer of the receptor assay technology to interested Member States and the establishment of the receptor assay method in these laboratories and these objectives address the need for a rapid and sensitive assay to complement and replace the current live mouse bioassay in order to enhance shellfish toxicity monitoring program and improve the management of harmful algal blooms (HABs). Towards these objectives, a Regional (RCA) Training Workshop on Receptor Binding Assay Techniques for Harmful Algal Bloom Toxins Quantification was conducted at the Philippine Nuclear Research Institute (PNRI) from 29 Nov - 04 Dec 1999 and it aimed to train the RCA Member States representatives in neuroreceptor binding assays for paralytic shellfish poisoning (PSP) toxins as an alternative method to mouse bioassay