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[en] Objective of a new method of FDG analysis development is to replace existing tests by a more complex assay. In this work, a liquid chromatography/refractive index detector/ radiometric detector/mass spectrometric detector combination (HPLC/RID/RAD/MSD) was used for development of a complex routine technique. Optimization of HPLC/MS analysis was performed investigating the MSD analytical signal as a function of various eluent composition. Solutions of glucose in methanol/water and acetonitrile/water solutions of various semi-volatile electrolytes (ammonium chloride, formic acid, ammonium formate) were analyzed on the Agilent 1100 HPLC/RID/DAD/MSD system either in the flow injection (FIA) mode of analysis, and after passing the samples through Zorbax C-18 column. The most intensive signals of the ions were obtained in the acetonitrile : 0.25% ammonium formate = 80:20 solutions. This eluent would be also used for the radioactive FDG analysis on the Asahipak NH2P columns. (authors)
Source
Kufcakova, J. (ed.); Macasek, F. (ed.); Rajec, P. (ed.) (Dept. of Nuclear Chemistry, Comenius University, Bratislava (Slovakia)); Foundation Curie, Bratislava (Slovakia); Department of Dept. of Nuclear Chemistry, Comenius University, Bratislava (Slovakia); 139 p; ISBN 80-223-1629-6; 
; 31 May 2001; p. 39; SIS'01: 9. international conference Separation of Ionic Solutes; Bratislava, Modra-Harmonia (Slovakia); 5-10 Jun 2001; PROHJECT TCP-SLR/2/002; Also available from Foundation Curie, Mlynska dolina CH-1, 84215 Bratislava, Slovakia; 4 refs.
; 31 May 2001; p. 39; SIS'01: 9. international conference Separation of Ionic Solutes; Bratislava, Modra-Harmonia (Slovakia); 5-10 Jun 2001; PROHJECT TCP-SLR/2/002; Also available from Foundation Curie, Mlynska dolina CH-1, 84215 Bratislava, Slovakia; 4 refs.