[en] As a generator-produced beta-emitting radionuclide, the importance of ¹⁸⁸Re for radionuclide therapy is increasing rapidly. We prepared ¹⁸⁸Re-tin colloid and compared its properties with ¹⁸⁸Re-sulfur colloid. Labeling efficiencies reached >98% for tin colloid at 2 h and 89-94% for sulfur colloid at 3 h. All the preparations were stable for 72 h in water, serum, and synovial fluid. If labeled at higher temperature, the particle size of tin colloid increased. The residual radioactivity of ¹⁸⁸Re-sulfur colloid in disposable polypropylene syringes after injecting mice was high (62.0±7.0%) due to its hydrophobic nature, while that of ¹⁸⁸Re-tin colloid was low (2.9±1.6%). Although both ¹⁸⁸Re-tin colloid and ¹⁸⁸Re-sulfur colloid might be useful for radionuclide therapy, we conclude that ¹⁸⁸Re-tin colloid is more advantageous over ¹⁸⁸Re-sulfur colloid, due to higher labeling efficiency, control of the particle size, and lower residual activity in the injection syringes