[en] The mechanism of formation of residual nuclei in the mass region 42≤A≤81 in the reactions of protons with separated tin isotopes at three protons energies 0.66, 1.0 and 8.1 GeV was investigated. The absolute cross-sections of the residual nuclei were compared with the theoretical ones calculated by the standard cascade-evaporation and the intranuclear cascad plus statistical multifragmentation models (INC+SMM). It was shown that at E_p=8.1 GeV these nuclei may arise both from disintegration of the nucleus and as partners of several fragments